Welcome to ATRIPLA.com. This is the place to learn about the first and only complete HIV (Human Immunodeficiency Virus) regimen in one pill daily. ATRIPLA is a prescription medicine used alone as a complete regimen or with other medicines to treat HIV infection in adults.

*ATRIPLA is a combination of three HIV medicines: SUSTIVA^® (efavirenz), EMTRIVA^® (emtricitabine) and VIREAD^® (tenofovir disoproxil fumarate).

ATRIPLA does not cure HIV and has not been shown to prevent passing HIV to others. Ask your doctor if ATRIPLA is right for you, and see your healthcare provider regularly.

IMPORTANT SAFETY INFORMATION
Contact your healthcare provider right away if you experience any of the following side effects or conditions associated with ATRIPLA:

• Nausea, vomiting, unusual muscle pain, and/or weakness. These may be signs of a buildup of acid in the blood (lactic acidosis), which is a serious medical condition.
• Light colored stools, dark colored urine, and/or if your skin or the whites of your eyes turn yellow. These may be signs of serious liver problems.
• If you have HIV and hepatitis B virus (HBV), your liver disease may suddenly get worse if you stop taking ATRIPLA. Do not stop taking ATRIPLA unless directed by your healthcare provider.

Do not take ATRIPLA if you are taking the following medicines because serious and life-threatening side effects may occur when taken together: Hismanal^® (astemizole), Vascor^® (bepridil), Propulsid^® (cisapride), Versed^® (midazolam), Orap^® (pimozide), Halcion^® (triazolam), or ergot derivatives (for example, Wigraine^® and Cafergot^®).

In addition, ATRIPLA should not be taken with: Combivir^® (lamivudine/zidovudine), EMTRIVA, Epivir^® or Epivir-HBV^® (lamivudine), Epzicom^™ (abacavir sulfate/lamivudine), SUSTIVA, Trizivir^® (abacavir sulfate/lamivudine/zidovudine), TRUVADA^® (emtricitabine/tenofovir DF), or VIREAD, because they contain the same or similar active ingredients as ATRIPLA.

Vfend^® (voriconazole) should not be taken with ATRIPLA since it may lose its effect, or may increase the chance of having side effects from ATRIPLA. Fortovase^®, Invirase^® (saquinavir) should not be used as the only protease inhibitor in combination with ATRIPLA.

Taking ATRIPLA with St. John’s wort (Hypericum perforatum) is not recommended as it may cause decreased levels of ATRIPLA, increased viral load, and possible resistance to ATRIPLA or cross-resistance to other anti-HIV drugs.

This list of medicines is not complete. Discuss with your healthcare provider all prescription and nonprescription medicines, vitamins, and herbal supplements you are taking or plan to take.

Contact your healthcare provider right away if you experience any of the following side effects or conditions:

• Severe depression, strange thoughts, or angry behavior have been reported by a small number of patients. Some patients have had thoughts of suicide and a few have actually committed suicide. These problems may occur more often in patients who have had mental illness.
• Dizziness, trouble sleeping or concentrating, drowsiness, unusual dreams and/or hallucinations are common, and tend to go away after taking ATRIPLA (efavirenz 600 mg/emtricitabine 200 mg/tenofovir DF 300 mg) for a few weeks. Symptoms were severe in a few patients and some patients discontinued therapy. These symptoms may become more severe with the use of alcohol and/or mood-altering (street) drugs. If you are dizzy, have trouble concentrating and/or are drowsy, avoid activities that may be dangerous, such as driving or operating machinery.
• Kidney or liver problems. If you have had kidney or liver problems, including hepatitis infection or take other medicines that may cause kidney or liver problems, your healthcare provider should do regular blood tests.
• Pregnancy: Women should not become pregnant while taking ATRIPLA. Serious birth defects have been seen in children of women treated during pregnancy with one of the medicines in ATRIPLA. Women must use a reliable form of barrier contraception, such as a condom or diaphragm, even if they also use other methods of birth control.
• Breast-Feeding: Women with HIV should not breast-feed because they can pass HIV through their milk to the baby. Also, ATRIPLA may pass through breast milk and cause serious harm to the baby.
• Rash is a common side effect that usually goes away without treatment, but may be serious in a small number of patients.
• Seizures have occurred in patients taking a component of ATRIPLA, usually in those with a history of seizures. If you have ever had seizures, or take medicine for seizures, your healthcare provider may want to switch you to another medicine or monitor you.
• Bone changes. If you have had bone problems in the past, your healthcare provider may want to check your bones.
• If you have ever had mental illness or use illegal drugs or alcohol.

Changes in body fat have been seen in some people taking anti-HIV medicines. The cause and long-term health effects are not known.

Common side effects of ATRIPLA include tiredness, headache, upset stomach, vomiting, gas, and diarrhea. Skin discoloration (small spots or freckles) may also happen with ATRIPLA.

You should take ATRIPLA once daily on an empty stomach. Taking ATRIPLA at bedtime may make some side effects less bothersome.

Please click here for Full Prescribing Information on this website, including "What is the most important information I should know about ATRIPLA?" in the Patient Information.