Medicines You Should Not Take with ATRIPLA
ATRIPLA may change the effect of other medicines, including the ones for HIV-1, and may cause serious side-effects.
Your healthcare provider may change your other medicines or change their doses.
Do not take ATRIPLA if you are taking the following medicines because serious and
life-threatening side effects may occur when taken together:
- Vascor® (bepridil)
- Propulsid® (cisapride)
- Versed® (midazolam)
- Orap® (pimozide)
- Halcion® (triazolam)
- Ergot medications (for example, Wigraine® and Cafergot®)
ATRIPLA should not be taken with the following medicines because they contain the same or similar active ingredients as ATRIPLA:
- Combivir® (lamivudine/zidovudine)
- COMPLERA® (emtricitabine/rilpivirine/tenofovir disoproxil fumarate)
- EMTRIVA® (emtricitabine)
- Epivir® or Epivir-HBV® (lamivudine)
- Epzicom® (abacavir sulfate/lamivudine)
- Trizivir® (abacavir sulfate/lamivudine/zidovudine)
- TRUVADA® (emtricitabine/tenofovir disoproxil fumarate)
- VIREAD® (tenofovir disoproxil fumarate)
- ATRIPLA should not be used with SUSTIVA® (efavirenz) unless recommended by your healthcare provider
(voriconazole) should not be taken with ATRIPLA since it may lose its effect or may increase the chance of having side effects from ATRIPLA.
Do not take St. John's wort (Hypericum perforatum) or products containing St. John's wort with ATRIPLA.
Taking St. John's wort may decrease ATRIPLA levels and lead to increased viral load, and possible resistance to ATRIPLA or cross-resistance to other anti-HIV-1 drugs.
ATRIPLA should not be used with HEPSERA®
It is also important to tell your healthcare provider if you are taking any of the following:
These are not all the medicines that may cause problems if you take ATRIPLA. Tell your healthcare provider about all prescription and nonprescription medicines, vitamins, or herbal supplements you are taking or plan to take.
- Fortovase®, Invirase® (saquinavir), Biaxin® (clarithromycin), Noxafil® (posaconazole), or Sporanox® (itraconazole); these medicines may need to be replaced with another medicine when taken with ATRIPLA
- Calcium channel blockers such as Cardizem® or Tiazac® (diltiazem);
Covera HS® or Isoptin® (verapamil) and others; Crixivan® (indinavir),
Selzentry® (maraviroc); the immunosuppressant medicines
cyclosporine (Gengraf, Neoral, Sandimmune, and others), Prograf (tacrolimus), or Rapamune (sirolimus); Methadone; Mycobutin® (rifabutin); Rifampin; cholesterol-lowering medicines, such as Lipitor® (atorvastatin); Pravachol® (pravastatin sodium); and
Zocor® (simvastatin) or the anti-depressant medications bupropion (Wellbutrin,Wellbutrin SR, Wellbutrin XL, and Zyban); or Zoloft® (sertraline); dose changes may be needed when these drugs are taken with ATRIPLA
- VIDEX®, VIDEX® EC (didanosine) and tenofovir DF (a component of ATRIPLA) may increase the amount of didanosine in your blood, which could result in more side effects. You may need to be monitored more carefully if you are taking ATRIPLA and didanosine together. Also, the dose of didanosine may need to be changed
- REYATAZ® (atazanavir sulfate) or Kaletra® (lopinavir/ritonavir); these medicines may increase the amount of tenofovir DF (a component of ATRIPLA) in your blood, which could result in more side effects. REYATAZ is not recommended with ATRIPLA. You may need to be monitored more carefully if you are taking ATRIPLA and Kaletra together. Also, the dose of Kaletra may need to be changed
- Medicine for seizures [for example, Dilantin® (phenytoin), Tegretol® (carbamazepine), or phenobarbital]; your healthcare provider may want to switch you to another medicine or check drug levels in your blood from time to time
Keep track of all your medicines to help your healthcare provider
Keep a complete list of all the prescription and non-prescription medicines as well as any herbal remedies that you are taking, how much you take, and how often you take them. Make a new list when medicines or herbal remedies are added or stopped, or if the dose changes. Give copies of this list to all of your healthcare providers and pharmacists every
time you visit your healthcare provider or fill a prescription. This will give your healthcare provider a complete picture of the medicines you use. Then he or she can decide the best approach for your situation.
ATRIPLA does not cure HIV-1 infection or AIDS
and you may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections.
See your healthcare provider regularly while taking ATRIPLA.
Please click here
for Important Safety Information, including information on buildup of lactic acid in the blood
, serious liver problems, and sudden worsening of hepatitis B virus.